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Lecturer, University of Health and Allied Sciences

Quality Assurance and Quality Control

Full Name
Emmanuel Orman

Email

UnderGrad Education
Pharmacy

Masters Eduction
Pharmaceutical Chemistry

PHD Education
Pharmaceutical Chemistry

Papers auhored by Emmanuel Orman

A comparative study of Ghanaian propolis extracts: Chemometric analysis of the chromatographic profile, antioxidant, and hypoglycemic potential and identification of active constituents
Diabetes is a disease characterized by high post-prandial glucose levels, which lead to other complications such as peripheral end organ damage. The use of enzyme inhibitors in the management of Type-2 diabetes ensure the control of blood glucose levels via the control of carbohydrate metabolism. The use of standard agents such as acarbose is associated with unwanted side effects hence the need to investigate other sources of antihyperglycemic agents. Propolis, a natural substance from bees, possesses diverse biological activities including antioxidant, antimicrobial and antidiabetic properties. However, the phytochemical content of propolis and its extracts may vary depending on the geographical area, the solvent of extraction and type of bees. This study represents the first attempt to compare different extracts of propolis from the same source in sub-Saharan Africa. In this study, the effect of solvent and source of Ghanaian propolis on parameters such as the total phenolic and flav

Development and Validation of UV-Visible Spectrophotometric Method for the Determination of 5-Hydroxymethyl Furfural Content in Canned Malt Drinks and Fruit Juices in Ghana
A simple, rapid, accurate, and less expensive spectrophotometric method has been developed for the quantitation of 5-hydroxymethyl furfural (5-HMF) levels in canned malt drinks and fruit juice drinks sampled in the Kumasi Metropolis, Ghana. The quantitation is based on the selective maximum absorption of ultraviolet radiation by 5-HMF at the wavelength (λmax) of 284 nm using acetonitrile : water (50 : 50 v/v) as the solvent system. The method was established to be specific, precise, and accurate over a concentration range of 0.001 mg/ml–0.02 mg/ml. 5-HMF levels in fruit juice samples (A1–A10) were between 0.132 mg/ml and 0.438 mg/ml, and these levels were shown to be comparable (t  =  2.200; p = 0.0553) to the contents in the canned malt samples (M1–M10) which were between 0.3140 mg/ml and 0.7170 mg/ml. The study failed to show any dependence of 5-HMF levels on the composition of the product as well as the manufacturing process adopted. The length of storage did also not significantly