Two compounds—IND-X (4-(2-(2,4-Dinitrophenyl) hydrazone) methyl)-2 methoxy phenol) and IND-Y (4-(2-(2,4-Dinitrophenylhydrazono) methyl) benzene-1,3-diol)—were synthesized and found to possess acid-base indicator properties. These compounds exhibit behavior similar to phenolphthalein, methyl orange, and methyl red, showing sharp color changes in acid, alkaline, and neutral pH solutions. They have applications in acid-base titrations and pharmaceutical assays for ibuprofen powder and tablets, validated according to Q2 (R1) guidelines. Additionally, they serve as alternative indicators for routine volumetric analysis and titrimetric analysis of ibuprofen-based samples and products

A hybrid of six 4-hydroxyindole azo compounds was synthesized using diazotization and coupling via electrophilic aromatic substitution. Infrared and UV-Vis spectroscopic studies characterized the compounds. Compound 4d exhibited the highest antimicrobial activity against Pseudomonas aeruginosa in the HTSPOTi assay. While the compounds didn’t significantly affect the panel of pathogens in the resistant modulation study, 4a and 4f inhibited biofilm formation in Pseudomonas aeruginosa and Staphylococcus aureus. Additionally, 4c and 4e showed biofilm inhibition potential against these bacteria, making them promising leads for new antibacterial agents against antimicrobial resistance.

Antacids are substances commonly used by patients to obtain fast symptomatic relief from dyspepsia. They are weak bases which neutralize excess gastric acid and subsequently raise the pH of the gastric contents. The potency of the antacids depends mainly on their acid neutralization capacity (ANC) and this can vary from one brand to another. Several dosage forms of antacids are available for use by patients. However, In Ghana, suspensions are the commonest dosage form of antacids which is preferred by patients. The objective of this study was to determine the acid neutralizing capacity of six (6) randomly selected brands of antacid suspensions on the Ghanaian market using potentiometric acid-base titration. The samples were coded A-F to avoid any bias in the study. All the sampled brands had more than one year to expiry as indicated on their label.